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Thiamin supplements may help protect heart failure patients

March 10th, 2010 by liverablative in Uncategorized · No Comments

Among patients hospitalized with core failure, give whole in three has deficient levels of thiamin, although thiamin deficiency was less common amid those patients who were intriguing vitamin supplements, according to a modish office in the Jan. 17, 2006, issue of the Journal of the American College of Cardiology.

“We found that one-third of congestive heart failure patients admitted to our hospital had red blood cell levels of thiamin that were lower than normal and would suggest deficiency. In contrast to some previous studies, we did not find a relationship between the development of thiamin deficiency and the amount or duration of diuretic use and urinary thiamin excretion. In fact, what was important was that a relatively small dose of thiamin from a multi-vitamin was protective against developing thiamin deficiency,” said Mary E. Keith, Ph.D. from St. Michael’s Hospital in Toronto, Ontario, Canada.


Dr. Keith said that heart failure may increase the body’s need for certain nutrients, including thiamin, so even patients who are eating relatively well may not be getting enough of them. At the same time, the illness may make it harder to maintain a proper diet. She said that this study helps focus attention on the role of diet in managing serious conditions, such as heart failure.


“Physicians and the public have exclusively focused on drug therapy to the detriment of at least one of the foundations of good health-appropriate nutrition,” she said.


Thiamin, also called vitamin B1, helps the body to digest carbohydrates and perform other functions. Like other B vitamins, thiamin is not stored in the body, so poor diet can lead to deficiency in a relatively short period of time and possibly worsen the symptoms of heart failure. Although thiamin deficiency has not been extensively studied among heart failure patients, the researchers said that there are several reasons to be concerned about the problem. For instance, many heart failure patients have poor diets, and some earlier studies have indicated that diuretic medicines prescribed to help treat the condition may increase the losses of thiamin.


This study is the largest study yet of thiamin deficiency among hospitalized heart failure patients, and it included participants with various degrees of illness. The researchers, including lead author Stacy A. Hanninen, R.D., M.S.C., measured the thiamin levels of 100 consecutively admitted patients with heart failure. They also measured the thiamin levels of 50 healthy people. The heart failure patients were almost three times as likely to be deficient in thiamin as the control subjects (33 percent versus 12 percent, p = 0.007).


“Our sample is quite representative of our hospitalized population of heart failure patients. We also used a direct measurement of thiamin status–the erythrocyte thiamin pyrophosphate–which is more specific than earlier assays that indirectly measured enzyme activity. Finally, our study also investigated factors other than diuretic medication, such as diet, medical status and demographic factors that might be contributing to the development of thiamin deficiency,” Dr. Keith said.


In contrast to earlier studies, these results did not show an association between the use of diuretic medications and thiamin deficiency. However, Dr. Keith said that their report is not the final word on this point.


“The relationships between thiamin loss, thiamin status and diuretic use are not definitively established and controversy remains. Our population was a cross-section of hospitalized patients who had differing levels of disease severity and had differing doses of diuretics prior to their admission, which may have accounted for the lack of relationship between diuretic dose and thiamin deficiency,” she said.


Dr. Keith also pointed out that although they observed that patients taking supplements were less likely to be deficient in thiamin, the association did not reach statistical significance (p = 0.06). Further studies are needed to determine whether improving thiamin levels, either with supplements or via other means, will improve heart failure symptoms.


Professor John G.F. Cleland, F.A.C.C., from the University of Hull in Hull, U.K, who was not connected with this study, said that there are many reasons for heart failure patients to have difficulties maintaining proper nutrition, so it is surprising that so little attention has been paid to nutrition in heart failure.


“Patients with advanced heart failure commonly suffer from cardiac cachexia, but little is known about the mechanisms underlying this problem or how to treat it. Deficiency in one dietary component, such as thiamin, is unlikely to occur in isolation and might be a marker for shortages of other micronutrients. Recent research suggests that targeted multi-micronutrient supplementation may improve quality of life and left ventricular function in elderly patients with heart failure,” Dr. Cleland said.


Jill Kalman, M.D. from the NYU Medical Center in New York, N.Y., who also was not connected with this study, said the results help point the way toward improving care for heart failure patients.


“If we can start to point out where there are certain metabolic deficiencies in heart failure, learn where we can replace them in an effective and safe fashion, and make a difference eventually in terms of outcomes, I think that’s where this is an important article,” Dr. Kalman said.


Dr. Kalman said that it is also important to find out whether any heart failure treatments may be causing metabolic deficiencies.


http://www.acc.org/

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Terrence Higgins Trust Offers Chlamydia Tests In Basildon Nightclub, UK

March 8th, 2010 by liverablative in Uncategorized · No Comments

On 28th September HIV and animal health dole Terrence Higgins Trust (THT) hand down be offering Chlamydia testing at Colors nightclub in Basildon. The testing will be offered to under 24’s from 9pm to midnight at the gay venue and is being undertaken in collaboration with South West Essex Make Vigilance Trust.

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Anyone who would correspondent to to fasten on the evaluation discretion be asked to confer a test - a urine sample for the men and a self captivated swab for the women - which they can do themselves in the reclusion of a facilities cubicle. The samples would then be labelled by the THT team and sent displeasing to a lab for testing. Results would be sent back to individuals by text or phone message (or another preferred method) within to 10 days to two weeks, with remedy and advice on what to do next if the examination is constructive.

Chlamydia is the most common sexually transmitted infection (STI) in the UK. As numberless as one in 10 down 24s are thought to be positive. Although it’s often meditation of as something that mainly affects women, in 2005 diagnoses rose by 7% in men. Chlamydia often doesn’t have any symptoms in men or women and if communistic untreated it can source complications.

Victoria Gamble, Services Manager for THT in Essex said “Many people don’t methodical contrive all round Chlamydia or going for STI testing so we’re taking the tests to them. It’ll take just 5 minutes out of their night but might pick up an undiagnosed infection which they can then get treated. We don’t want any shyness on the incessantly, we hope to bother lots of people charming the test!”

If the chlamydia testing is a achievement, THT and South West Essex Primary Care Trust may look at oblation chlamydia testing in other venues locally.

http://www.tht.org.uk

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Cell detachment model for an antibody-based microfluidic cancer screening system

March 6th, 2010 by liverablative in Uncategorized · No Comments

In the pursue to perceive more types of cancers at ever earlier stages, researchers keep been stymied by a lack of stall surface markers that judge in a clear-cut manner between healthy and malignant cells.

Often, these efforts attempt to find markers whose levels differ greatly between healthy and malignant cells, but such markers have proven elusive. Using a computer modeling approach, researchers at Texas Tech University have shown that microfluidics may be able to identify malignant cells based on different levels of given markers.


Jordan Berg, Ph.D., and his colleagues approached this problem as one of optimizing small differences in the ability of antibodies to bind to and release from cells containing varying levels of a given tumor marker on their surfaces. Presumably, cells with higher levels of the marker would bind more often to an antibody immobilized within the channels of a microfluidics device than would a cell with lower levels of the marker. As a result, cells with a higher level of the marker – malignant cells, for example – would move more slowly through the device than would healthy cells that had lower levels of the marker. These differences can be small, though, so the operating parameters of the microfluidics device would have to be near perfect to separate cells based on small differences in antibody binding.


To determine what those operating parameters should be, the investigators crafted a computer model for cell transport through a microfluidics device loaded with an antibody to a marker known as æ6 integrin, which is present in higher levels in cells infected with human papillomavirus (HPV), the cause of almost all cases of cervical cancer, as well as some other types of tumors.

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The results of this modeling effort, which the investigators published in the journal Biotechnology Progress, revealed that flow rate was the critical operating parameter that needed to be carefully controlled to maximize the discrimination between healthy and malignant cells expressing this antigen on their surfaces. The researchers showed, too, that they could use the model to analyze cell movement through the device and generate a quantitative measure of HPV infection.


This work is detailed in a paper titled, “Cell detachment model for an antibody-based microfluidic cancer screening system.� This paper was published online in advance of print publication. An abstract of this paper is available at the journal’s website. View abstract.


http://nano.cancer.gov

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Breast-Feeding Benefits Should Be Disseminated, But Women Who Formula-Feed Should Not Be Harshly Criticized, Editorial Says

March 3rd, 2010 by liverablative in Uncategorized · No Comments

Although “science comes down on one’s uppers on behalf of educating women about the clear advantages of tit-feeding,” it is “no empower to advert to that mothers who cannot breast-feed or opt not to are putting their babies in grave threat,” a New York Times editorial says (New York Times, 7/2). An HHS toss one’s hat in the ring called “Healthy People 2010″ aims to hold 50% of women who delivered infants to continue breast-feeding for up to six months after emancipation. The campaign has received criticism that it overstates the benefits of soul-feeding and could make women who cannot breast-sustain, or who opt not to, undergo ashamed and inadequate (Kaiser Daily Women’s Healthfulness Policy Report, 6/13). The American Academy of Pediatrics has cited “strong evidence” that breast-feeding can reduce amount of diarrhea, respiratory infections, ear infections and other catching diseases in infants, according to the Times editorial. For this, the “government is redress to let out the tidings that, all things being adequate for,” women should breast-provision, but experts “on both sides” of the distribution agree there are “safe and nutritious” feeding formulas, the op-ed article says. Some women reveal teat-feeding “painful” and others have difficulty pumping wring at beget, the opinion piece says, adding that society should “encourage employers” to provide adequate places for women to pump knocker milk but people should not “houn[d] those who decide” not to heart of hearts-pasturage (New York Times, 7/2).

“Reprinted with permission from http://www.kaisernetwork.org. You can view the whole Kaiser Habitually Fitness Procedure Report, search the archives, or augury up seeking email delivery at http://www.kaisernetwork.org/dailyreports/healthpolicy. The Kaiser Commonplace Form Procedure Report is published fit kaisernetwork.org, a free service of The Henry J. Kaiser Division Foundation . © 2005 Advisory Board Company and Kaiser Family Basis. All rights prim.

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Whole Blood Sensor Research Could Transform Cardiac Testing

March 2nd, 2010 by liverablative in Uncategorized · No Comments

University of Ulster researchers have teamed up with scientists at the Indian Association of Technology, Bombay on a project to arise low-volume whole-blood sensors that could transform incidental-of-care cardiac testing.

Securely, accurate blood study is vital in the treatment of people agony sentiments attacks or other life-menacing cardiac events, said Professor Jim McLaughlin, Top banana of UU’s Nanotechnology & Advanced Materials Research Institute, who leads the project team.

“If you have a suspected core infect medical staff will monitor your ECG, respiration rate, SP02 and eye dilation.

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“But it is also vitally top-level that your blood is analysed as despatch as thinkable. Analysing cardiac enzymes in the blood will enable medical staff to determine the correct treatment. It determination orientate them on whether to execute clot-busting drugs, insert a stent or attempt defibrillation, for example.”

The sensor system under maturity whim use carbon nanotubes to filter out blood cells preventing them from adhering to the sensor, or distorting the result.

Conventional uses of the technology group monitoring of cardiac enzymes, e.g. troponin I, to aid in the diagnosis of a cardiac start, clinch the severity and also monitor recovery afterwards.

The ultimate application will be well-connected in cases where defibrillators are used; cardiac rehabilitation; bed-side monitoring; triage scenarios and at the scene of an emergency.

The UU/IIT Bombay energy is part of the UK-India Education and Investigate Initiative (UKERI), a arrange funded by the governments of the UK and India, for collaborative projects between instructional institutes in the two countries.

The UKERI engagement has enabled the recruitment of four new PhD students who entertain already started at UU, and is expected to pull more PhD exchanges as it progresses. The first formal meeting between the researchers took suitable on 25-28th of September 2007 at the University of Ulster.

ULSTER UNIVERSITY
York Street
Belfast
BT15 1ED

http://www.ulst.ac.uk

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New Way To Analyze Sleep Disorders

March 1st, 2010 by liverablative in Uncategorized · No Comments

Log a few zees Z’s is such an essential somewhat by of human duration that we splurge to a third of our lives doing it — some more successfully than others. Sleep disorders afflict some 50-70 million people in the Joint States and are a major cause of bug and injury. People who suffer from disturbed sleep have an increased risk of quintessence disparage, tittle, hypertension, obesity, depression, and accidents. Virtually a fifth of all serious wheels crashes, in happening, are linked to sleeplessness.

Diagnosing saw wood disorders is not necessarily elementary. In criterion “sleep studies,” people throw away one or more nights at hospitals or other inpatient centers, sleeping while sensors and electrodes attached to the head and torso record breathing, brain waves, middle rate, and other vital signs.

Now, a group of scientists in Israel and Germany has discovered a open new way to monitor doze and potentially diagnose drowse disorders straight by recording someone’s nerve rate. Their method relies on using a mathematical knack to analyze these recordings and worry out gen related to the synchronization between heartbeat and breathing, which energy be a stamp of fitness of the cardio-respiratory organized whole.

Their work may individual day mitigate clinicians more easily pinpoint siesta disorders and determine optimal treatments representing people with congestive heart failure. Athletes capability also be able analyze their own recordings to optimize workouts.

Conducted by researchers at Technische Universität Ilmenau in Germany, Bar-Ilan University in Ramat Gan, Israel, Martin-Luther-Universität Halle-Wittenberg in Germany, and Schlafmedizinisches Zentrum der Charité Berlin, the induce appears in a special focus number of the journal Pandemonium, which is published by the American Institute of Physics (AIP). The special issue is focused on nonlinear dynamics in cognitive and neural systems. It asks how chaos affects certain discernment areas and presents interdisciplinary approaches to various problems in neuroscience — including sleep disorders.

Monitoring the heartbeat provides information about breathing because the two physiological processes are weakly coupled. During inhalation, the heart beats faster. During puff, the pump slows down. These effects are seen during sleep as trickle. Moreover, the heart price and breathing scold also change across certain stages of sleep. They are faster and fluctuate more during impetuous peer at action (REM) catch forty winks than they do during fervent sleep, for as it happens.

In their new study, the Israeli and German scientists showed that the synchronization between the heartbeat and breathing pattern is significantly enhanced during non-fluctuating stages of sleep. By mathematically analyzing someone’s heart rate throughout the night, they could gain information on that person’s breathing and catnap stage.

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They looked at data from the European project SIESTA, which keeps a database of take facts recorded in seven countries from 295 people — about half of whom have sleep disorders. Subjects of this study spent two nights in sleep laboratories, slumbering while electrodes connected to their heads and torsos monitored things relish brain and muscle motion, heart rate, and eye movement. This collection of physiological data is what normally enables doctors to reconstruct the phases of sleep and identify repose disorders.

The Israeli and German scientists analyzed just the soul data for the 150 people in the SIESTA study who deceive no known take a nap disorders. They then used the heartbeats to reconstruct the breathing patterns, and they showed that these reconstructions accurately cogitate about the solid recorded breathing data unruffled in siesta labs. Additionally, looking at the synchronization between heartbeat and breathing, the assemblage could pretentiousness that there is a significant relationship between sleep stages and cardio-respiratory synchronization patterns, i.e., heartbeat and breathing mostly synchronize during non-REM sleep (light and strong the ocean sleep), and cardio-respiratory synchronization is on the verge of wanting during REM sleep.

Next they sketch to extend their study to people with sleep disorders to determine whether their modus operandi can accurately diagnose these disorders. Analyzing the heartbeat using their dexterousness may also reveal information fro cardiorespiratory capacity, which may lead to diagnostic markers of cardiac diseases and ways to infer optimal treatments for people with congestive pump non-performance. Monitoring cardiorespiratory aptitude may also take atheletes optimize workout routines.

The article “Automated synchrogram analysis applied to heartbeat and reconstructed respiration,” by C. Hamann et al. appears in Chaos 19, 015106 (2009).

ABOUT THE JOURNAL CHAOS

Chaos, published by the American Found of Physics, is devoted to increasing the mind of nonlinear phenomena and describing the manifestations in a manner comprehensible to researchers from a broad spectrum of disciplines.

ABOUT AIP

The American Pioneer of Physics (AIP) is a not-for-profit membership corporation chartered in 1931 during the purpose of advancement and diffusion of the knowledge of physics and its application to compassionate good fortune. An umbrella organization into 10 Member Societies, AIP represents over 134,000 scientists, engineers and educators and is one of the world’s largest publishers of physics journals. A total-conclusion provider of publishing services, AIP also publishes 12 journals of its own (many of which obtain the highest impact factors in their category), two magazines, and the AIP Colloquy Proceedings series. Its online publishing platform Scitation (registered trademark) hosts more than 1,000,000 articles from more than 175 ivory-towered journals, as well as forum proceedings, and other publications of 25 au fait haut monde publishers.

Source: American Institute of Physics (AIP)

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Minimally Invasive Endograft Offers Superior Results

February 28th, 2010 by liverablative in Uncategorized · No Comments

Traditionally thoracic aortic aneurysm disease has been treated with surgery requiring a brawny chest slash and placement of a synthetic corruption to repair the artery. However, a new learning indicates that use of the minimally invasive W.L. GORE TAG® Thoracic Endoprosthesis to treat descending thoracic aneurysms appears to be superior to open surgical condition in anatomically suitable patients.

Investigator Ellen D. Dillavou, MD, from the division of vascular surgery at the University of Pittsburgh Medical Center, said this is the commencement study to look at the long-expression (five-year) outcomes of the two procedures. “Our researchers studied outcomes of the IDENTIFY endograft after its implantation in 140 patients compared to 94 patients who had compare favourably with aneurysms repaired by open surgery, between September 1999 and May 2001, as well as 51 more patients who were added in 2003 after revamping of the endograft.” The extended-term track-up of the multi-center monogram trial which took place at centers completely the United States, is detailed in the May 2008 issue of the Journal of Vascular Surgery.

Follow-up consisted of steadfast visits, computed tomography scans and X-rays at one and six months, then annually for five years. “Initially and at five years, TAG patients had cured results,” said Dr. Dillavou. “At five years aneurysm-related mortality was 2.8 percent compared to 11.7 percent in gaping surgery patients, and major adverse events were 57.9 percent vs. 78.7 percent. Endoleaks in STICKER patients decreased from 8.1 percent at one month to 4.3 percent at five years.”

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There were no aneurysm ruptures reported in either group through the study space and no deaths due to aneurysm-correlated causes after one year in either squad. At five years, secondary procedures in the TAG aggregation were lower (15.0 percent vs. 31.9 percent) and numerous were managed with a minimally invasive approach. On the contrary five EARMARK patients underwent major aneurysm-related re-interventions (3.6 percent), including one shrewd aneurysm repair, one open aneurysm repair and three patients with minimally invasive procedures for endoleaks.

Dr. Dillavou added that at five years, aneurysm sac size decreased in 50 percent of the patients and increased in 19 percent of them, compared to the lone-month baseline. Comparison with the modified low-porosity device at two years showed sac increase in 12.9 percent of original vs. 2.9 percent in modified grafts. “Although sac enlargement is with an eye to, break of dawn modified device results indicate this outgoing may be resolved,” said Dr. Dillavou.

“Prior to this story it was not known if minimally invasive repairs would be as durable as accustomed open repairs,” said Dr. Dillavou. “This study demonstrates that in suitable patients, endovascular fix up of thoracic aneurysms has clear and lasting advantages over open aneurysm repair and that the ATTEND endograft is durable to five years of carry on-up. This work confirms that the early advantages of minimally invasive endovascular thoracic aneurysm repair carry on to five years of follow-up. TAG patients had fewer deaths and complications from their aneurysms, making this the safest approach to suitable patients.”

About Journal of Vascular Surgery

Memoir of Vascular Surgery provides vascular, cardiothoracic and general surgeons with the most recent information in vascular surgery. Original, peer-reviewed articles cover clinical and exploratory studies, noninvasive diagnostic techniques, processes and vascular substitutes, microvascular surgical techniques, angiography and endovascular management. Special issues publish papers presented at the annual convergence of the Journal’s sponsoring camaraderie, the Society suitable Vascular Surgery. Visit the Record trap purlieus at http://www.jvascsurg.org.

About the Society for Vascular Surgery

The Society for Vascular Surgery (SVS) is a not-for-profit culture that seeks to advance pre-eminence and alteration in vascular health through education, advocacy, research and public awareness. SVS is the national supporter recompense 2,400 vascular surgeons dedicated to the prevention and panacea of vascular disease. Visit the website at http://www.VascularWeb.org.

Society for Vascular Surgery
633 N. St. Clair, 24th Fl.
Chicago, IL 60611
United States
http://www.jvascsurg.org

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Czech Government has not fully answered charges of forced sterilizations of Romany women

February 26th, 2010 by liverablative in Uncategorized · No Comments

The U.N. Commission on the Elimination of Insight Against Women this week is expected to finalize and release a draft report that says the Czech Republic ministry has not completely answered allegations that more than 80 Roma, or Gypsy, women from 1986 through 2004 were sterilized in the country without informed concurrence, the Christian Science Monitor reports.

Forced sterilizations of Roma women also have been reported in Hungary, Bulgaria and Romania, according to the Monitor (White, Christian Science Monitor, 9/6).


A 2003 report from the Center for Civil and Human Rights and the Center for Reproductive Rights cited 110 cases of Roma women who claim to have been forcibly sterilized since 1989 in state hospitals in eastern Slovakia because of widespread prejudice and fear against the Roma population.


Despite the long history of forced sterilization in the region, Slovakian officials had denied the report’s findings of acts of intimidation, and physicians denied sterilizing patients (Kaiser Daily Women’s Health Policy Report, 3/7/03).


The U.N. report comes after the December 2005 release of a Czech Public Defender of Rights report on the cases that said the charges against the government were justified and called on the government to revise its policy on sterilization and compensating people forced to undergo such procedures.

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According to the Monitor, the U.N. committee plans to call for similar legislative changes.


Many of the cases involve Roma women giving birth for the second time by caesarean section who were told by physicians - often minutes before delivery - that a tubal ligation was necessary to avoid a third pregnancy and c-section, the Monitor reports.


Some of the women say they falsely were told that the procedure was reversible.


The health ministry said it is investigating the cases.


A ministry spokesperson said that Roma women were not singled out for sterilization and that charges of sterilization without consent in recent years are “misleading and without merit.”


An Ostrava, Czech Republic, court in 2005 was the first court in the country to rule against a hospital in a sterilization case, saying physicians failed to obtain consent in the 2001 sterilization of Helena Ferencikova.


The hospital, which was ordered to apologize, is appealing the ruling (Christian Science Monitor, 9/6).

This article is republished with kind permission from our friends at the The Kaiser Family Inauguration. You can representation the entire Kaiser Daily Haleness Policy Report, search the archives, or sign up seeing that email delivery of in-depth coverage of health policy developments, debates and discussions. The Kaiser Every day Health Policy Report is published into Kaisernetwork.org, a free secondment of The Henry J. Kaiser Family Foundation. Copyright 2006 Advisory Board Company and Kaiser Family Foundation. All rights ice-cold.

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Surprising new theory on antibiotic resistance

February 24th, 2010 by liverablative in Uncategorized · No Comments

A surprising further theory developed at the University of Nebraska Medical Center (UNMC) in Omaha, Nebraska, suggests that some bacterial cells resolution as “suicide bombers” in cell communities, with the altruistic ambition of dying for the stale good - and in the method, strengthening other cells that then behoove unruly to antibiotic drugs.

The finding could aid future research into developing drugs that can skirt the potentially catastrophic problem of bacterial resistance to antibiotics.


In a paper published April 23 in Proceedings of the National Academy of Science , Kenneth Bayles, Ph.D., of UNMC, writes that “programmed cell death� in bacterial communities is a form of altruism that benefits the larger community of cells and helps strengthen them.


“People get caught up in the idea that altruism is a behavior that requires deep thought, planning, and feelings such as caring,� Bayles said. But he argues through his research that altruism appears to be an innate function in cell death, or “lysis.�


Three years ago, Dr. Bayles, a professor of pathology and microbiology at UNMC, began growing cells in biofilm to observe how communication between cells – known as “quorum sensing� – affects their survival.


He observed that when cells are forming a biofilm – a colony of bacteria that contains resistant organisms and is involved in many antibiotic-resistant infections – they perform a function that enables them to leave a unique imprint on the world: their DNA. A small percentage of cells explode in a process called “lysis,� leaving behind a sticky residue that contains DNA and other cellular bioproducts which are then incorporated into the larger cell community to build a stronger biofilm.


“For a long time, microbiologists viewed bacteria as wholly simplistic organisms that lived alone and died alone,� said Dr. Bayles, noting that the discovery of “quorum sensing� nearly 40 years ago was a giant leap forward in understanding the complexity of communication and interaction between cells. “My research takes the concept to the extreme, with the idea that a fraction of the bacterial population actually dies for the good of the community.�


Dr. Bayles’ hypothesis could represent a paradigm shift in one of the cornerstones of microbiology, because understanding how cells die naturally – or how they commit “suicideâ€? – could yield entirely new ways of killing them clinically. Previously, programmed cell death has been observed only in higher species.

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He compares the process to what happens in a colony of honeybees or ants, which share 75 percent of their DNA. If something endangers one of them, a few others react altruistically – stinging intruders to defend the colony. “Sting once, and you’re dead, but it’s for the good of the colony,â€? Dr. Bayles said. Because bacteria in a biofilm share 100 percent of their DNA, their “suicide missionâ€? is more pronounced; instead of just a few cells dying, many die and leave behind their DNA, thus strengthening the survivors.


Researchers have struggled with the question of why biofilms are extremely resistant to antibiotic drugs. “We don’t know why, but we think it’s because the cell death function is suppressed in the cells that don’t commit suicide, making them tolerant to antibiotics,â€? Dr. Bayles said. “In biofilm infections, if we can turn the cell death function back on, we can make them less resistant to antibiotics. Our research uncovers new targets for antibiotics, which we desperately need.â€?


Programmed cell death in mammals is a major topic in cancer research, and Bayles said his findings could potentially aid researchers trying to develop cancer drugs.


Bayles’ findings are bound to be controversial, because he assigns a highly intellectual characteristic to these bacterial cells, although he says this altruistic behavior is likely an innate function.


“This has been brewing for the past 15 years, but now we’ve made this leap and we can say we’ve seen programmed cell death in biofilm,â€? Dr. Bayles said. “Some microbiologists have been slow to accept that programmed cell death makes sense in bacteria because they are single-celled, but many are now coming around to the idea.â€?


http://www.unl.edu/

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The world’s population in 2050 will be 9.276 billion, currently 6.396 in 2004

February 22nd, 2010 by liverablative in Uncategorized · No Comments

The Population Reference Subdivision has released the 2004 World Population Data Gazette. The strange data is in these times the most up-to-date world demographic information and makes estimates for all countries and regions of the world. It also highlights key world demographic shifts between now and 2050.

The world’s population in 2050 will be 9.276 billion, currently 6.396 in 2004.
By 2050, India will have overtaken China as the most populous country with 1.628 billion people compared to China’s later people of 1.437 billion.
Developing countries in Africa and Asia will account for about 90 percent of the inflation in incredible citizens projected by 2050, while the populations of most developed countries will decrease. Among the developed countries, exclusively the In accord States is promising to organize momentous growth, a effect of immigration and a delivery chew out higher than other developed nations.
Niger is expected to be the fastest-growing country between now and 2050, rising from million to 53 million. Bulgaria will decline most, from 8 million to about 5 million.
Globally, birth rates range dramatically from 1.2 to 8 children per woman. In some African and Middle Eastern countries, women common at hand six to eight births in their lifetimes. In Europe, the common falls extreme short of two children. Such depraved rates will ensure population diminution and, in many European countries, the annual number of births is less than the count of deaths.
Family planning profit by is becoming more widespread in developing countries to help women avoid unintended pregnancies and to lessen birth rates. A clear prerequisite is the availability of modern contraception for couples with both the knowledge and desire to contemn it. This objective has been generally achieved in much of Latin America and the Caribbean, but often falls quite short in sub-Saharan Africa and parts of Asia and Oceania. In each region, contraceptive use varies broadly. Obstacles such as the lack of funds and supplies —and the be without of comprehensive programs to educate couples on their options—are significant barriers.
The United States has one of the highest birth rates expanse developed countries, with a perfect fertility regardless of 2.0. Other developed countries have fertility rates lower or much lower than 2.0.
Despite improvements, each year an infant is 13 times more expected to ache in Africa as in Europe or North America. The lack of prenatal and postnatal care, resulting from the lack of facilities, trained professionals, or unconsciousness of the need for professional care, are noteworthy contributors to high rates of infant mortality. The fact that high rates remain in various countries does mask the reality, however, that real progress has been made. In Africa, rates attired in b be committed to been halved since 1950, showing that maternal and child health programs do profession.
The number of people again living with HIV/AIDS has reached 38 million, according to the Shared Nations. Sub-Saharan Africa has by far the largest number of people living with HIV/AIDS, just over 25 million. Out of the 6.5 million HIV/AIDS victims in South/Southeast Asia, 5.1 million live in India. It is estimated, however, that infection rates have begun to decline in a several of countries, so that the situation requisite not be hopeless.

http://www.prb.org


The full PDF version can be found here http://www.prb.org/pdf04/04WorldDataSheet_Eng.pdf

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